SUMMARY Cisapride is a newly developed substance that stimulates gastrointestinal motility, possibly enhancing acetylcholine release in the gut wall. The aim of our study was Received for publication 1 June 1984 oesophageal motility in healthy human subjects. It was realised that the lower oesophageal sphincter pressure is not constant. In the fasting state the lower oesophageal sphincter pressure shows substantial fluctuations which appear to be related to the interdigestive migrating complex.3 4 Furthermore, the lower oesophageal sphincter pressure changes after consumption of a meal, the effect depending on the composition of the meal.5-Whether amplitude and duration of the contractions in the oesophageal body are likewise related to motility patterns in the upper gut is not known. Therefore, the study was designed such that the effect of cisapride on oesophageal contractions and lower oesophageal sphincter pressure could be OCH3 OCH3

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