The half-neutralization potentials (HNP) of a series of biologically active fluoromethanesulfonamides were determined in 67% N, N-dimethylformamide-water. A plot of aqueous pKa vs. HNP for nine methanesulfonamides and fluoromethanesulfonamides in the series was used to calculate the pKa's of the remaining water-insoluble sulfonamides. The pKa's of eight aryl-substituted 1,1,1 -trifluoro-lV-phenylmethanesulfonamides correlated better with the Hammett substituent constant than with ~or
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