The objective of this study is to evaluate the osteoconductivity and bioactivity of the Bonelike Õ graft in repairing surgical cystic bone defects. Bonelike Õ is implanted in 11 patients, aged between 24 and 53 years with a mean age of 36 years, consisting of 5 men and 6 women. According to the standard follow up protocols, radiological examinations are performed and Bonelike Õ /bone retrieved samples have been analyzed histologically using nondecalcified sections obtained perpendicular to bone length axis. Radiographic examination and histological results clearly demonstrate an extensive new bone formation apposed on Bonelike Õ granules with a significant degree of maturation. These clinical applications in maxillary bone defects indicate perfect bone bonding between new bone formed and Bonelike Õ granules, along with partial surface biodegradation. This quick and effective osteoconductive response from Bonelike Õ may reduce the time needed to reconstruct the bone defected area of patients.

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BonelikeÒ graft that mimics the inorganic composition of bone tissue has been developed and characterized over the last decade. To evaluate the osteoconductivity of BonelikeÒ two granule size ranges, one ranging from 150-250µm and the other from 250-500µm were implanted in the femurs of New Zealand White rabbits, aiming at being clinically used in different medical applications, such as dentistry and orthopaedics. In order to facilitate the medical application of the BonelikeÒ graft the use of a commercially available polymeric vehicle was also analyzed. Radiological examination, histological studies and scanning electron microscopy (SEM) analyses revealed that the surface of Bonelike® granules was almost completely surrounded by new bone formation after 12 weeks of implantation, which proves its highly osteoconductive behaviour.

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