Assessment of Bonelike® graft with a resorbable matrix using an animal model

Lobato, J.V.; Hussain, N. Sooraj; Botelho, C. M.; Maurício, Ana Colette; Afonso, Américo; Ali, Nasar; Santos, J. D.

doi:10.1016/j.tsf.2005.12.153

Cited by 13 publications

(12 citation statements)

References 35 publications

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“…For both ceramics, histological and SEM results revealed a very satisfactory osteointegration, signs of bone graft degradation, and simultaneous occurrence of bone ingrowth. These results are in agreement with the experimental and clinical observations made with Bonelike V R polygonal granules 24,[27][28][29] and with some other calcium phosphate-based bone grafts. 55,56…”

Section: Discussionsupporting

confidence: 91%

“…The above‐referred properties might explain the significant osteoblast differentiation and proliferation, as well as bone mineralization, observed in in vitro studies 16–23. Data obtained from in vivo animal studies, where bone defects were surgically created, revealed a very satisfactory osteointegration and a sustained controlled resorption of Bonelike® 12, 24–29. All these experiments were performed with Bonelike® polygonal granules obtained by crushing, which consist of irregular fragments with a great variability in the size and the degree of porosity, because of the destruction of the surface layer during the crushing procedures 30.…”

Section: Introductionmentioning

confidence: 99%

“…[16][17][18][19][20][21][22][23] Data obtained from in vivo animal studies, where bone defects were surgically created, revealed a very satisfactory osteointegration and a sustained controlled resorption of Bonelike V R . 12,[24][25][26][27][28][29] All these experiments were performed with Bonelike V R polygonal granules obtained by crushing, which consist of irregular fragments with a great variability in the size and the degree of porosity, because of the destruction of the surface layer during the crushing procedures. 30 Additionally, these granules have sharp areas that may adversely affect osteogenesis.…”

Section: Introductionmentioning

confidence: 99%

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Characterization and preliminary in vivo evaluation of a novel modified hydroxyapatite produced by extrusion and spheronization techniques

et al. 2011

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A glass-reinforced hydroxyapatite (HA) composite, recently registered as Bonelike®, was developed for bone grafting. This biomaterial is composed of a modified HA matrix with α- and β-tricalcium phosphate secondary phases and ionic species that mimic the chemical composition of human bone. Several in vitro and in vivo studies have confirmed the benefits of these properties. However, these studies were all executed with Bonelike® polygonal granules obtained by crushing. In this study, Bonelike® pellets were produced through a patented process, which required the use of techniques such as extrusion and spheronization. The final product presented a homogeneous size, a 55.1% global porosity and a spherical shape. This spherical shape permitted a better adaptation to the implantation site and improved injectability. Additionally, it also may contribute to formation of macropores as pellets packaging leaves open spaces. After implantation of Bonelike® polygonal granules and Bonelike® pellets in monocortical defects in sheep for 8 and 12 weeks, light microscopy and scanning electron microscopy showed extensive osteointegration simultaneously with bone regeneration for both presentations. Histomorphometric analysis did not reveal statistically significant differences between defects treated with Bonelike® polygonal granules and Bonelike® pellets, which suggests similar in vivo performances.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Characterization and preliminary in vivo evaluation of a novel modified hydroxyapatite produced by extrusion and spheronization techniques

et al. 2011

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“…Such composite is reported to stimulate new bone formation more quickly than commercial HA, in particular during early periods of implantation. 142,207,233,234 Bonelike V R grafts in particulated form have been also successfully employed in several clinical applications, namely in maxillofacial and oral surgery, orthopaedics, and implantology. [235][236][237][238][239][240][241][242][243][244][245] Radiological and histological investigations demonstrated that such composite is highly bioactive, it is rapidly osteointegrated after implantation and it resorbs at a rate that is compatible with the new bone formation.…”

Section: Phosphate Glass Additionmentioning

confidence: 99%

Hydroxyapatite and tricalcium phosphate composites with bioactive glass as second phase: State of the art and current applications

Bellucci

Sola

Cannillo

2015

J Biomedical Materials Res

117

102

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Calcium phosphates are among the most common biomaterials employed in orthopaedic and dental surgery. The efficacy of such systems as bone substitutes and bioactive coatings on metallic prostheses has been proved by several clinical studies. Among these materials, hydroxyapatite (HA) and tricalcium phosphate (TCP) play a prominent role in medical practice since the '80s. In the last years, numerous attempts to combine HA or TCP with bioactive glasses have been made. There are two main motivations for sintering calcium phosphates with a glassy phase: on the one hand, it is possible to tune the dissolution of the final system and to enhance its biological response through the synergistic combination of two bioactive phases; on the other hand, the glass acts as a sintering aid with the aim to increase the densification of the composite and thus its mechanical strength. In this sense, TCP and HA are penalized by their relatively poor fracture toughness and tensile strength compared to natural bone, which makes it impossible to use them in load-bearing applications. Moreover, the bioactivity index of pure calcium phosphates is typically lower with respect to that of many bioactive glasses. In this review, the state of the art and current applications of composites, based on HA or TCP with bioactive glass as second phase, are presented and discussed. A special emphasis is given to the processing and mechanical behaviour of these systems, together with their biological implications, as a function of the composition of the glass employed as second phase.

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“…Arthrodesis using Bonelike ® as a bone graft promotes bone fusion that permitted the horse to return to the athletic activity and improved the horse quality of life, decreasing the pain and increasing the joint stability. The Bonelike ® application can enhance the bone production due to osteoinductive and osteoconductive proprieties, shortening the healing period after the arthrodesis and promoting the joint fusion in a shorter period [68,74]. These three clinical cases were strongly evidenced that Bonelike ® is an appropriate synthetic bone graft substitute with osteoconductive and osteoinductive properties to be used in surgical arthrodesis, as void space filler, associated or not with standard orthopaedic procedures of stabilization of the joints, in order to promote a faster bone fusion without any local or systemic adverse reaction.…”

Section: Scaffolds In Tissue Engineering -Materials Technologies Andmentioning

confidence: 99%

Clinical Application of Macroporous Ceramic to Promote Bone Healing in Veterinary Clinical Cases

Pinho¹,

Campos²,

Mendonça³

et al. 2017

Scaffolds in Tissue Engineering - Materials, Technologies and Clinical Applications

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Autogenous cancellous bone is the most effective material in promoting rapid healing and still considered the "gold standard" for evaluation of bone graft substitutes. The harvesting process to collect autologous bone is associated with complications and its availability is limited. Allogenic bone is another alternative with osteoconductive properties, and it act as a structural graft when applied in defects of long bones, but some disadvantages are also associated. The development of the bone grafts substitutes has gained tremendous popularity over the last two decades. Osteoconductive materials act as scaffolds were cells from the surrounding tissues with osteogenic capacities can lay new bone, and may be produced using different types of agents, such as bone products, ceramics, bioactive glasses, collagen, polymers, and composites. Bonelike ® is produced by the incorporation of P 2 O 5 -CaO glass-based system within a hydroxyapatite matrix. Bonelike ® Poro consists of polygonal granules with 2000-2800 μm and 4000-5600 μm of diameter with pore sizes range from 100 to 400 μm. This chapter will focus on the different techniques were this ceramic synthetic bone substitute was used to promote bone regeneration with special attention in both experimental and clinical cases of veterinary orthopaedics in dogs and cats, horses and ruminants, including results obtained with Bonelike ® .

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Assessment of Bonelike® graft with a resorbable matrix using an animal model

Cited by 13 publications

References 35 publications

Characterization and preliminary in vivo evaluation of a novel modified hydroxyapatite produced by extrusion and spheronization techniques

Characterization and preliminary in vivo evaluation of a novel modified hydroxyapatite produced by extrusion and spheronization techniques

Hydroxyapatite and tricalcium phosphate composites with bioactive glass as second phase: State of the art and current applications

Clinical Application of Macroporous Ceramic to Promote Bone Healing in Veterinary Clinical Cases

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