The detection of HAA was proved positive in 6 cases out of 7 histologically confirmed PAN.The presence of HAA does not necessarily depend on the evidence of hepatic manifestations. In those 7 cases were indeed observed 2 initial icteric hepatitis biologically and histologically proved, 4 transitory hepatomegalies, and in the last case (which was not the HAA negative one), no hepatic manifestation could be detected. It was possible to prove for at least 4 patients that they did not receive transfusions previously. The detection of HAA was performed by immunodiffusion test only, and our results were controlled in Paris and Lyon. In 2 cases the antigen and the antibody were observed simultaneously.Apparently the antigen appears very precociously and persists for a fairly long time because we can follow its persistency after 30 months in 1 case. To explain these facts, 3 hypothesis can be proposed:1. HAA is not specific of viral hepatitis.2. PAN realizes a highly propicious ground, regarding eventually immunodepressive or corticosteroid therapy, to the development of a subacute anicteric hepatitis with persistant antigenemia as in Down's syndrome.3. Viral hepatitis with HAA seem to represent a disease with antigen-antibody circulating complexes, which could provoke the injuries of PAN.
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