A b s t r a c t A r t i c l e I n f oThe leaves and root samples of Calotropis gigantea were screened for its antimicrobial and phytochemical activities. Solvent extraction was performed using solvents namely methanol, ethanol, isopropanol and hexane. Phytochemical analysis revealed the presence of alkaloids, flavonoids, steroids, terpenoids, phenols and tannins in both root and leaves extracts. In leaves, anthraquinone was present. In case of hexane only alkaloids, tannins and carbohydrates were present. Antimicrobial activity was performed against opportunistic pathogenic bacterial strains such as Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Klebsiella pneumonia using the disc diffusion method. The methanolic extract of root of Calotropis gigantea inhibited P. aeruginosa with a maximum zone of inhibition (18 ± 0.5 mm) at the maximum concentration tested. Hexane extract exhibited low inhibition activity. Similarly, the methanolic extract of leaves exhibited a zone of inhibition of 27± 0.8 mm against P. aeruginosa. The results were compared with standard antibiotics ampicillin, vancomycin and tetracycline. In present study, methanolic extract was found to exhibit effective anti-bacterial properties which could be attributed to the presence of phytochemical present in the extract.
Medicinal plants have been an important part in the healthcare management using traditional medicine. They have contributed to the generation drugs and in the treatment of various diseases. Cellular damage caused by reactive oxygen species (ROS) has been implicated in several diseases. Cancer is a major public health burden in both developed and developing countries. Anticancer activit of natural and synthetic or biological and chemical agents to reverse, suppress or prevent carcinogenic progression. Several synthetic agents are used to cure the disease but they have their toxicity and hence the research is going on to investigate the plant derived chemotherapeutic agents. Natural antioxidants have significant importance in human health. gigantea, a medicinal plant has been reported to possess different therapeutic properties. In the present study, in vitro antioxidant status and anti carcinogenic properties of C. gigantea were analysed using most commonly accepted assays that is reducing power assay and DPPH assay. The in vitro cytotoxic activity of C. gigantea extract using the MTT assay against MCF-7 and PC-3 cell lines.
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