The approximations necessary t.o conipare theory and performance in largescale chromatographic colunins are critically analyzed. The existence of carrier gas velocity gradients across the column cross section is the major cause of band-broadening and inefficiency in large-scale columris. Estimates of these radial velocity gradients based oil existing particle size and velocity measurements are shown to be too inexact to test the presently accepted theory. A radial velocity profile, which has the major features of profiles measured in somewhat similar systems, is proposed. The need for accurate measurements of velocity profiles is emphasized.
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