The importance of nonlinear acoustic wave propagation and ultrasound-induced cavitation in the acceleration of thermal lesion production by high intensity focused ultrasound was investigated experimentally and theoretically in a transparent protein-containing gel. A numerical model that accounted for nonlinear acoustic propagation was used to simulate experimental conditions. Various exposure regimes with equal total ultrasound energy but variable peak acoustic pressure were studied for single lesions and lesion stripes obtained by moving the transducer. Static overpressure was applied to suppress cavitation. Strong enhancement of lesion production was observed for high amplitude waves and was supported by modeling. Through overpressure experiments it was shown that both nonlinear propagation and cavitation mechanisms participate in accelerating lesion inception and growth. Using B-mode ultrasound, cavitation was observed at normal ambient pressure as weakly enhanced echogenicity in the focal region, but was not detected with overpressure. Formation of tadpole-shaped lesions, shifted toward the transducer, was always observed to be due to boiling. Boiling bubbles were visible in the gel and were evident as strongly echogenic regions in B-mode images. These experiments indicate that nonlinear propagation and cavitation accelerate heating, but no lesion displacement or distortion was observed in the absence of boiling.
Electromagnetic acoustic transducers (EMATs) generate ultrasonic waves in metals through an electromagnetic coupling mechanism. A concept for EMAT generation, using a coil alone without a permanent magnet, but with a pulse generator and a sample, is introduced. A simplified equivalent coil circuit is given and has been validated by experimental measurements. Such an equivalent circuit can be used for variations in excitation current calculations, which have often been neglected in previous publications in this area but have proved to be of great importance in considering the efficiency and frequency characteristics of ultrasonic generation. The equivalent coil inductance is dependent on the distance between the coil and the sample, due to coil interactions with eddy currents and the Ampere current of the magnetization mechanism. Analytical solution for an annular coil above metal samples is given, and the influences of the lift-off, coil radius, material magnetic permeability and electrical conductivity on the equivalent coil inductance are discussed. Experimental measurements agree well with predictions.
A solution of gold chloride was reduced using ultrasound irradiation to prepare metallic gold nanoparticles under conditions of microgravity and normal gravity at sea level. Particle size distributions were measured using TEM analysis. A mean particle diameter of 10 nm was obtained in microgravity while a mean diameter of 80 nm was obtained in the laboratory. Absorbance measurements on the reacted solution found an enhanced reduction rate in the reduction of gold chloride in microgravity compared to that in the laboratory.
This long-term ecological study confirms that rates of penetrating trauma increase with increasing unemployment rates. This should inspire further research to identify areas of greatest need to improve delivery of resources and current public policy with the ultimate goal of decreasing the incidence of penetrating trauma.
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