Magnetic
hyperthermia treatment using calcium phosphate nanoparticles
is an evolutionary choice because of its excellent biocompatibility.
In the present work, Fe3+ is incorporated into HAp nanoparticles
by thermal treatment at various temperatures. Induction heating was
examined within the threshold Hf value of 4.58 ×
106 kA m–1 s–1 (H is
the strength of alternating magnetic field and f is
the operating frequency) and sample concentration of 10 mg/mL. The
temperature-dependent structural modifications are well correlated
with the morphological, surface charge, and magnetic properties. Surface
charge changes from +10 mV to −11 mV upon sintering because
of the diffusion of iron in the HAp lattice. The saturation magnetization
has been achieved by sintering the nanoparticles at 400 and 600 °C,
which has led to the specific absorption rate of 12.2 and 37.2 W/g,
respectively. Achievement of the hyperthermia temperature (42 °C)
within 4 min is significant when compared with the existing magnetic
calcium phosphate nanoparticles. The systematic investigation reveals
that the HAp nanoparticles partially stabilized with FeOOH and biocompatible
α-Fe2O3 exhibit excellent induction heating.
In vitro tests confirmed the samples are highly hemocompatible. The
importance of the present work lies in HAp nanoparticles exhibiting
induction heating without compromising the factors such as Hf value, low sample concentration, and reduced duration
of applied field.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.