chromosomal abnormalities have been shown to characterize certain subg roups of & T umor-speci c mesenchymal neoplasms. Identi cation of these abnormalities has proven useful diagnostically and has provided direction for molecular studies of pathogenetically important genes. Recent studies focusing on cytog enetic and molecular cytog enetic nding s in osteosarcoma have expanded our knowledge of chromosomal alterations in this neoplasm and are pointing to recurrent reg ions of interest. In our study, the cytog enetic ndings of 36 osteosarcoma specimens and a review of the literature ( f or a total of 161 specimens) are provided. M olecular cytog enetic studies were performed on two specimens. Clonal chromosomal abnormalities were detected in 25 of 36 specimens and included 17 near-diploid, 8 near-triploid, 2 near-tetraploid, and 8 specimens with multiple clones of diå erent ploidy levels. Examination of the present data and previously published results reveals that chromosomal bands or reg ions 1p11-13, 1q11-12, 1q21-22, 11p14-15, 14p11-13, 15p11-13, 17p, and 19q13 are most f requently rearranged, and the most common numerical abnormalities are + 1, -9, -10, -13, and -17. T he majority of osteosarcomas examined were characterized by complex karyotypes.
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