Build-up, plateau, and depletion of tissue residues of an organic arsenical (roxarsone: 4-hydroxy-3nitrobenzene-arsonic acid) administered in the feed to growing chickens are compared to total arsenic residues in chickens receiving nonmedicated feed. Spectrophotometric determination of residues was based on the procedure given by Winkler, using silver diethylthiocarbamate. Total residues and rates of depletion were established using four tissues (muscle, skin, liver, and kidney) from each of four birds of each sex sacrificed on scheduled days.Highest residues were found in the liver, and significant sex differences were not observed. Rapid depletion of residues occurred during the first five days off medication. Roxarsone(4-hydroxy-3-nitrobenzenearsonic acid or, more commonly, 3-nitro-4-hydroxyphenylarsonic acid) has been administered in the feed of poultry and swine for about 20 years for growth promotion and improvement of the efficiency of feed utilization. Medication with roxarsone produces residues in edible tissues which are measured as elemental arsenic as reported by Kerr et al. (1963). This report, which was a compilation of data from animals maintained under varying conditions, also included levels
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