The present work describes a novel method for the synthesis of silver polymer nanocomposite for the delivery of amoxicillin (AMO). Silver nanoparticles (AgNPs) were synthesized with chitosan and silver nitrate. The reaction parameters were optimized. Three-dimensional polymeric networks were synthesized by simple free-radical graft copolymerization. UV-visible spectroscopy, Fourier transform infrared spectroscopy, X-ray diffraction, SEM, atomic force microscopy, dynamic light scattering, and zeta potential analysis were used for the complete characterization of the samples. Swelling studies and swelling factors were evaluated. In vitro release of AMO and AgNPs at physiological pHs was analyzed using the Peppas kinetic model to explain the drug delivery mechanism. Cytotoxicity, free-radical scavenging, and antibacterial activities were analyzed. V C 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43479.