A new Zn based complex with oxalate, namely [NH 2 (CH 3 ) 2 ][Zn(Ox) 1.5 ] ⋅ DMF ⋅ H 2 O (I) (Ox = oxalate), has been synthesized and structurally characterized. Single crystal X ray analysis of compound I re veals that the Ox ligand links the Zn(II) center, generating an intricate 2D classical honeycomb like archi tecture (CIF file CCDC no. 1028787). The detail analyses of Hirschfeld surface and fingerprint plots gave a mode of non covalent interactions in the title compound.
Here, a sandwich-type electrochemical immunosensor was constructed to detect cardiac troponin I (cTnI) via asymmetric bowl-shaped PdAgFe mesoporous nanospheres (PdAgFe ABMS) as a signal amplification label and core-shell cubic Au/Co-LDH@ZIF-67 as a substrate material. PdAgFe ABMS prepared by dual-template directional anisotropic island growth method has abundant mesoporous channels to accelerate molecular mass transfer in solution. In particular, the asymmetric bowl-like structure allows more active sites to be exposed, which improves the utilization of atoms to stabilize and high current response signals. The synergistic effect between PdAgFe increased the activation energy of the catalytic reaction and further amplified the current signal. In addition, the biosensing interface based on Au/Co-LDH@ZIF-67 not only exhibits a high electron transfer rate, but also can capture more bioactive molecules. Under optimal conditions, the constructed immunosensor was detected to exhibit a low limit of detection (LOD, 4.47 fg/mL) and a wide detection range (10 fg/mL - 100 ng/mL). This work provides an accurate and convenient scheme for the clinical detection of cTnI.
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