During the development of the murine heart, a variety of electrophysiological changes takes place: both the levels of expression of ion channels and their regulatory properties are altered (Kojima et al. 1990;Maki et al. 1996). During early murine embryogenesis, it has been shown that the L_type Ca¥ channel current (ICa) plays a dominant role in excitation, whereas the slow component of the delayed rectifier K¤ channel current (IK,s) is not so apparent until the later stages of embryonic development, or even after birth (Honore et al. 1991;Davies et al. 1995). Also, during development of the mouse heart, the â_adrenergic signalling pathway has been found to be functionally incomplete until
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.