The stop-flow technique has been applied to the dog in an attempt to rule out tubular secretion of phosphate and to locate the site of action of parathyroid hormone (P.T.H.) on the renal tubule. Under the experimental conditions used, no significant inward transtubular movement of P³² could be demonstrated, ruling out tubular secretion of phosphate. Stop-flow experiments performed in parathyroidectomized dogs before and after P.T.H. administration demonstrated inhibition of phosphorus reabsorption by the hormone. In addition, the stop-flow pattern indicated that this phenomenon took place mainly in the distal part of the proximal tubules.

No abstract

No abstract

Mulder H, Koster J, Hackeng WHL, van der Schaar H. Normocalcaemic hyperparathyroidism after parathyroidectomy: a retrospective study. Scand J Clin Lab Invest 1993; 53: 607-610.Forty-eight patients with proven hyperparathyroidism underwent parathyroidectomy. All patients were post-operatively normocalcaemic and free of symptoms due to their pre-operative hypercalcaemic state. However, 20 (42%) post-operative patients still had increased serum PTH and low serum phosphate levels.

No abstract