Status of thiamin in the elderly North American population is reviewed. Most Americans eat sufficient thiamin but about 5% of those over 60 yr old show impaired thiamin status. This is more marked in the poor, those confined in institutions, or those with illness. Thiamin responsive heart disease and Wernicke Korsakoff CNS syndromes occur in the elderly but there is no increased prevalence. Minor heart or neurological syndromes related to thiamin deficiency cannot be identified. The Recommended Dietary Allowance of thiamin provides at least 50% excess thiamin for those over 60 yr old--this amount is adequate. There is no known toxicity for thiamin.
5. Tobacco mosaic virus, Bacillu8 megaterium and cells of the Ehrlich ascites tumour have been treated with 35S-labelled mustard gas; the extent of reaction with nucleic acid has been determined and shown to be about the same as that with protein. The site of reaction with nucleic acid has been shown, as in the case of pure nucleic acid, to be at N-7 of guanine moieties. 6. Mice bearing the Ehrlich ascites tumour have been injected with 35S-labelled mustard gas and the nucleic acid of the tumour cells shown to have reacted in the same way as in vitro. 7. Previous work on the reactions of alkylating agents with nucleic acids is discussed in relation to the present findings.
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