Background and Purpose-Little is known about the relative efficacy of supervised versus unsupervised community exercise programs for stroke survivors. This study compared the effectiveness of a 10-week supervised strengthening and conditioning program (supervised) with a 1-week supervised instruction program followed by a 9-week unsupervised home program (unsupervised) and evaluated retention of changes at 6 months and 1 year after program completion. Methods-Seventy-two subjects retained at baseline (27 women, 45 men; meanϮSD age, 64.6Ϯ11.8 years) were randomly allocated to receive the supervised or unsupervised program. The primary outcome was walking speed over 6 minutes, and secondary outcome measures were Human Activity Profile, Medical Outcome Study 36-Item Short-Form survey (SF-36), Physiological Cost Index, and lower extremity muscle strength. Results-The 6-minute walking speed increased significantly in both groups and remained significantly improved by 1 year. The Human Activity Profile demonstrated an increasing trend only in the supervised group that was significant by 1 year. The SF-36 Physical Component summary score increased significantly in the supervised group and remained improved by 1 year; the unsupervised group showed significant improvement at 1 year. Women made greater gains in supervised programs, but men made greater gains in unsupervised programs. Conclusions-Supervised exercise programs and unsupervised programs after initial supervised instruction were both associated with physical benefits that were retained for 1 year, although supervised programs showed trends to greater improvements in self-reported gains. Gender differences require further research. (Stroke. 2006;37:476-481.)
This study compared the kinematic and electromyographic (EMG) gait patterns of able-bodied adults at natural speed in contrast to extremely slow overground and treadmill walking speeds. Kinematic and EMG data were collected at three speeds (self-selected, 0.30 m/s, and 0.20 m/s). Eighteen subjects were evaluated for trunk and lower-limb motion and EMG of five lower-limb muscles. Significant reductions were found in segmental motion between natural speed and both slower gait speeds, accompanied by an expected reduction in cadence and stride. EMG patterns at slower speeds showed changes in timing and reduced magnitudes. Phasic timing of the proximal muscles showed the most changes with predominant coactivation, whereas the distal muscles remained consistent with the pattern at natural self-selected speed. Overground versus treadmill gait patterns revealed minimal differences. Consideration of the effects of slower walking speed may help clinicians create interventions to target primary gait deficits on overground or treadmill walking.
Animal and human research have shown that the drug 4-aminopyridine (4-AP) may improve gait in spinal cord lesions by enhancing nerve transmission to affected muscles. Study design: Prospective, randomized, double-blind, placebo-controlled, crossover trial. Objectives: To determine the efficacy of 4-AP in improving lower limb muscle strength and biomechanical gait patterns of chronic spinal cord injuries (SCI). Setting: The Rehabilitation Centre (Ottawa, Canada). Methods: In all, 15 chronic, ambulatory SCI persons were randomized to an initial 2 weeks of 40 mg/day, oral medication of either placebo or immediate-release, 4-AP and subsequently crossed over to the alternate medication for the following 2 weeks. Evaluations were conducted at baseline (before starting 4-AP or placebo medication), 2 weeks, and 4 weeks. Measures included dynamometer lower limb isometric muscle force and biomechanical gait measures including temporal-spatial parameters, electromyographic activation patterns, joint kinematics and kinetics. Subjective impressions of the drug by the participants were obtained from an exit survey. Results: Despite some positive comments from subjects, statistical and clinical analyses showed no within-subject differences between placebo and 4-AP measures of lower limb muscle force and objective gait analyses (ANOVA statistic P40.05). Conclusion: Results demonstrated the importance of placebo-controlled trials and quantitative outcome measures for the evaluation of 4-AP aimed to enhance gait for chronic, ambulatory SCI persons. Energy expenditure measures and mood may relate more to subjective comments and is suggested for future investigations.
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