A suspected case of chronic granulocytic leukaemia (chronic myelogenous leukaemia) with eosinophil differentiation and hepatic involvement is described in a 3–5‐year‐old rottweiler dog. Neoplastic eosinophilic infiltrates were also present in the lungs, kidneys, mesenteric lymph nodes and peribronchial and prester‐nal lymph nodes. Both pleural and abdominal effusions contained predominantly eosinophils and their precursors. The bone marrow showed an increase in the myeloid to erythroid ratio and an increase in the marrow granulocyte reserve. The majority of cells identified within the bone marrow were of the eosinophil series. Myelocytes and promyelocytes predominated.
Raw milk samples from 73 individual milk producers were obtained at the three main Dairy Marketing Board (DMB) collection centers in Zimbabwe during the period of January to February, 1988. The samples were examined for the presence of antibiotics using the Delvotest-P (Gist-Brocades) ampoule test method with a sensitivity of 0.002 I.U. of penicillin per ml of milk. Four samples (5.5%) contained more than 0.005 I.U. of penicillin per ml or equivalent. Two (2.8%) samples contained antibiotics other than penicillin. An antibiotic depletion study using 23 cows treated with a multiple antibiotic intramammary infusion product, streptomycin - penicillin mixture (Dispolac RX4 B®; Coopers, South Africa), indicated a withholding period of 7–8 d was necessary to obtain milk free of detectable residues. The sensitivity of the Delvotest-P for streptomycin was determined by the manufacturers and found to be 4–6 μg/ml.
Laryngeal dysfunction due to neoplastic disease is rare. Consequently, little is known about the behaviour or treatment of these tumours (Crow 1980). Clinical signs common to most laryngeal tumours include hoarseness and sometimes complete loss of voice (Wheeldon and others 1982). The signs develop over many months and later include stertorous breathing and dyspnoea (Harvey 1981). This case report was a malignant melanoma of the larynx and perilaryngeal tissues.
Povidone-iodine caused peritonitis with neutrophilic leukocytosis and a minimal left shift at the dosage rate of 3.5 ml/kg body weight. A dosage rate of 2 ml/kg only caused slight neutrophilic leukocytosis. There was a significant increase in the levels of creatinine (p = 0.049) and BUN (p = 0.020) in dogs that received the higher dose rate. Two dogs died from povidone-iodine toxicity with a marked increase in ALT, AP, SDH and conjugated bilirubin. It is concluded that povidone-iodine is unsafe for use in the peritoneal cavity of dogs.
Five cases of gonitis in young cows are reported. In all cases lameness was severe with no weight bearing on the affected limbs. The joints were swollen. No organisms were isolated from the fluids aspirated from the joints but cytological examination showed large numbers of neutrophils, and biochemical analysis showed increases in the activities of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and lactate dehydrogenase.
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