Feed is the most critical factor in animal production and the availability of cheap and high-quality feeds are crucial to sustainable livestock production. With the persistent scarcity and high cost of core feed inputs, the use of additives to increase feed use and economic efficiency through improved animal health and performance has gained popularity over the years. In recent times, non-antibiotic feed supplements, such as prebiotics, probiotics, enzymes, herbal mixtures and clay minerals have been tested as effective feed additives in animal diets. Organic acids and probiotic products are dietary feed additives with growth-promoting abilities similar to antibiotics. However, palm sap, an alcoholic beverage from various palm species has shown promise as a potential source of organic acids and direct-fed microbial products. Thus, this review provides a brief discussion on the microbial and biochemical characteristics of palm wine and its potential benefits to the livestock industry to improve performance, increased digestive efficiency, reduce the proliferation of pathogenic organisms and disease incidence in animal production. From the kinds of literature reviewed, it can be concluded that the metabolic products of palm wine fermentation had bacteriostatic and bactericidal properties to inhibit pathogens while improving the growth performance of animals.