SUMMARY Three hundred and thirty-four monoclonal gammopathies were detected in the sera of 30 279 adults from Finistere.Monoclonal gammopathies (MG) are more common in Finistere than in Paris and their distribution is not homogeneous. IgG paraproteins are particularly common in the northeast of Finistere whereas IgM paraproteins are more common in the southwest. Family studies and the high degree of inbreeding would support the hypothesis that there is a genetic predisposition to develop MG but the occurrence of paraproteins among three non-consanguineous couples seems to favour the existence of an environmental factor.

No abstract

The strongly intracontinental Tian Shan region, in Central Asia represents a key area to understand the long term evolution of continents in general and Asia in particular. If its Paleozoic and Cenozoic geodynamics are well understood, its Mesozoic evolution remains poorly constrained. In order to decipher the paleogeographic and large-scale tectonic evolution of the Tian Shan area during the Jurassic, we compiled, detailed field analyses of sedimentary rocks acquired within and around the Chinese Tian Shan region together with previously published data. We present three paleogeographical maps corresponding to the late Earlyearly Middle Jurassic, late Middleearly Late Jurassic and Late Jurassic-Early Cretaceous transition periods. We provide a large-scale picture of the Jurassic paleogeographic and climatic evolution of the Tian Shan region and discuss the geological