Kaposi’s sarcoma (KS) is the most common malignancy observed in patient with acquired immune deficiency syndrome (AIDS). It rarely causes upper airway obstruction. We report a 39-year-old gentleman, a former intravenous drug user with AIDS and Hepatitis C positive who developed progressive hoarseness with stidor. He underwent an emergency tracheostomy and direct laryngoscopy revealed a whitish globular laryngeal mass obscuring the glottic region. A biopsy of the mass was taken and the histopathological report showed evidence of spindle cell connective tissue, consistent with Kaposi’s sarcoma. It is important for clinicians or surgeons to maintain a high index of suspicion for the diagnosis of laryngeal KS in immunodeficiency patient even without cutaneous manifestation.Keywords: Airway obstruction; Laryngeal; Kaposi’s sarcoma; HIV. DOI: 10.3329/bjms.v9i2.5660Bangladesh Journal of Medical Science Vol.09 No.2 Apr 2010 pp.107-109