In this work, we study a family of Cremona transformations of weighted projective planes which generalize the standard Cremona transformation of the projective plane. Starting from special plane projective curves we construct families of curves in weighted projective planes with special properties. We explain how to compute the fundamental groups of their complements, using the blow-up-down decompositions of the Cremona transformations, we find examples of Zariski pairs in weighted projective planes (distinguished by the Alexander polynomial). As another application of this machinery we study a family of singularities called weighted Lê-Yomdin, which provide infinite examples of surface singularities with a rational homology sphere link. To end this paper we also study a family of surface singularities generalizing Brieskorn-Pham singularities in a different direction. This family contains infinitely many new examples of integral homology sphere links, answering a question by Némethi.
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