Columns containing different types of cyclodextrin derivatives have been evaluated for chiral gas chromatographic separation of atropisomeric PCBs, o,p9-DDT and o,p9-DDD. Separation was attempted on columns containing mixed chiral selectors, and the performance of two closely related selectors was also examined. The cyclodextrins were: permethylated-b-CD (PM-b-CD), heptakis(2,3-di-O-methyl-6-O-tert-butyldimethylsilyl)-b-CD (2,3-M-6-TBDMS-b-CD), heptakis(2,3-di-O-methyl-6-O-tert-hexyldimethylsilyl)-b-CD (2,3-M-6-THDMS-b-CD), and heptakis(2,3-di-O-ethyl-6-O-tert-hexyldimethylsilyl)-b-cyclodextrin (2,3-E-6-THDMS-b-CD). The cyclodextrins were dissolved in OV-1701 or in a dimethylsiloxane/silarylene copolymer containing 5% phenyl in the backbone. The application of mixed chiral selectors led to improved separations, however; at most eleven PCB congeners were separated on a single column. Chiral resolution of o,p9-DDD was achieved. The use of a dimethylsiloxane/silarylene copolymer as a matrix for the cyclodextrins is a promising approach. With such a matrix, blocking of the CD cavities by silicone substituent groups can be avoided, and a reasonable CD solubility can be provided. The selectivity of heptakis(2,3-di-O-ethyl-6-O-tert-hexyldimethylsilyl)-b-CD and heptakis(2,3-di-O-methyl-6-O-tert-hexyldimethylsilyl)-b-CD was quite different, the former selector could separate four congeners, while the latter separated ten congeners.
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