SUMMARYWe evaluated the effects of anti-inflammatory drugs in a murine model of allergic bronchopulmonary aspergillosis(ABPA). Mice instilled with 100 iigof Aspergi/lu.v fumigatu.s antigen (intranasally, 3 days a week for 3 weeks) developed pulmonary lesions, characterized by a perivascular and pcribronchial eosinophil infiltration, a bronchoaiveoiar Iavage (BAL) eosinophilia, and elevated levels of tolal IgE, total igGI and A. fumigatus-spccific IgGl, Under the same conditions, groups of mice receiving a daily dose of 2 mg/kg dexamcthasone showed decreased numbers oi' eosinophils and lolal cells in BAL, had less numerous eosinophils in their pulmonary infiltrates, and had lower levels ofserum and BAL fluid total IgE, total IgGl and A. fumigatu.s-spec\fic IgGl. Conversely, groups of mice pretreated with an immunosuppressive agent, cyclosporin A (CsA)at adoseof 5()mg/kg, three times per week, developed pulmonary lesions with enhanced lung cosinophilic influx and increased total IgE levels, both in serum and in BAL lluid. These findings show thai dexamelhasone polenlly prevents the murine immunopathologic response to A. fumigatus. The eflect of CsA on this inflammatory response was paradoxical, insofar as it suggests an activation ofthe T helper 2 subset, which Lip-rcguiales cosinophii recruitment and IgK production.Keywords Aspergitlus fumigaius pulmonary eosinophilia dexamcthasonc cyclosporin A total and specific hypergammaglobuUnaemia ABPA
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