The rapid deployment of wind and solar energy generation systems has resulted in a need to better understand, predict, and manage variable generation. The uncertainty around wind and solar power forecasts is still viewed by the power industry as being quite high, and many barriers to forecast adoption by power system operators still remain. In response, the U.S. Department of Energy has sponsored, in partnership with the National Oceanic and Atmospheric Administration, public, private, and academic organizations, two projects to advance wind and solar power forecasts. Additionally, several utilities and grid operators have recognized the value of adopting variable generation forecasting and have taken great strides to enhance their usage of forecasting. In parallel, power system markets and operations are evolving to integrate greater amounts of variable generation. This paper will discuss the recent trends in wind and solar power forecasting technologies in the U.S., the role of forecasting in an evolving power system framework, and the benefits to intended forecast users.
An integrated laboratory experiment
applying concepts and techniques
from organic chemistry, inorganic chemistry, and instrumental analysis
is presented for use in the undergraduate curriculum. This experiment
highlights the synthesis, characterization, and use of tris(2-pyridylmethyl)amine
(TPMA) to make complexes with different metal salts. It incorporates
laboratory practices such as literature searches, multistep synthesis,
reaction mechanisms, NMR spectroscopy, and X-ray crystallography.
Bartonella bacilliformis (B. bacilliformis), Bartonella henselae (B. henselae), and Bartonella quintana (B. quintana) are bacteria known to cause verruga peruana or bacillary angiomatosis, vascular endothelial growth factor (VEGF)-dependent cutaneous lesions in humans. Given the bacteria’s association with the dermal niche and clinical suspicion of occult infection by a dermatologist, we determined if patients with melanoma had evidence of Bartonella spp. infection. Within a one-month period, eight patients previously diagnosed with melanoma volunteered to be tested for evidence of Bartonella spp. exposure/infection. Subsequently, confocal immunohistochemistry and PCR for Bartonella spp. were used to study melanoma tissues from two patients. Blood from seven of the eight patients was either seroreactive, PCR positive, or positive by both modalities for Bartonella spp. exposure. Subsequently, Bartonella organisms that co-localized with VEGFC immunoreactivity were visualized using multi-immunostaining confocal microscopy of thick skin sections from two patients. Using a co-culture model, B. henselae was observed to enter melanoma cell cytoplasm and resulted in increased vascular endothelial growth factor C (VEGFC) and interleukin 8 (IL-8) production. Findings from this small number of patients support the need for future investigations to determine the extent to which Bartonella spp. are a component of the melanoma pathobiome.
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