RESUMEUne methode &extraction rapide sur cartouche C18 de la & h e urinahe est prop& envuedu dosage par chrmnatographieenphase gazeuse dansle cadre des umtr6les antidopage chez les sportifs. Le choix de Petalon et des conditions o p btoires a etd guidd par la n M t d de disposer dime dthode rapide. L'extraction de la caf&e en phase inverse C 1 8 est obtenue avec un rendement de 98 % et un coefficient de variation de 3 Yo. Dans ces conditions, un & a hnage interne a l'extraction n'a pas etd jug6 nkssaire. L'etalon interne choisi pour la chromatographie &azeuse est l'amobarbital en laisan de sea avantages : temps de n5-tention, stabilitd thermique, i n M t en fragmentom&ie de masse. 2621 C o p y r b t 0 1989 by Marcel Dekker, Inc. ABSTRACT A mpid method for Urinary caffeine excractiOnon C18 carhidge before GC determination is pmposed in view of doping m t r & in sport ?he choice of the standard and of the analytical procedure has been directed by the necessity of rapid determinati on.Caffeine extraction on C18 reverse-phase is achieved with a good efficiency (recovery : 98 %, CV = 3 Om), so that use of an intemal standard was not found necessary. A m O~l t a l was c h m as internal standard in Gc because of several advantages : retention time, thermal stability, interesting properties in mass fYagmenm e w .
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