We have evaluated the peripheral blood progenitors harvest. Nineteen patients started stem cell mobilization, one failed mobilization (5%) and 18 patients mobilized (95%). Nine out 18 patients did not reinfuse and 9 reinfused: 7 (24%), after a median follow up of 24 months, are alive and without evidence of disease, 1 was in partial remission and 1 progressed immediately after transplant. The overall survival and progression free survival are reported in Figures 1 and 2. Sixteen patients (89%) mobilized after 1 or 2 apheresis and the other two patients after three or four. The mean number of CD34+ cells mobilized was 5.8, the median number was 5.5 (IQR: 5 -6.75). The mean number of reinfused CD34+ cells in the 9 patients was 4.1, the median number was 4.1 (IQR: 3.5 -5). Summary/Conclusion: The association of Obinutuzumab and DHAP did not pass the interim analysis because a lower rate of CMR reported in comparison with the hypothesis. To note that seven patients (4 refractory and 3 relapsed) among the nine transplanted are alive and free from disease after a median follow-up of 24 months. Obinutuzuamb associated with a standard mobilizing chemotherapy (DHAP) did not compromise stem cell mobilization and engraftment after ASCT in this group of DLBCL patients.
A nonlinear dynamical model for the plankton population in a fixed sea area under the influence of asymmetric multiple factors, including atmospheric CO2 concentration, atmospheric temperature, nutrient concentration, seawater temperature, light intensity, and predator density is proposed to address the survival of the plankton population due to global warming. The model’s accuracy is confirmed by comparison with actual data, and numerical simulations are carried out to justify the relevant findings. The results suggest that increasing plankton’s ability to absorb atmospheric CO2 or regulate atmospheric temperature can help to mitigate global warming. Furthermore, if the population density of fish, the primary predator of plankton, falls within a certain range, the increase in atmospheric temperature will be mitigated. Additionally, the stability conditions for the suggested model are obtained, along with the equilibrium point of the system. Overall, this paper considers the effects of asymmetric multifactor interaction on plankton population density and establishes a mathematical connection between environmental ecosystems and plankton that might aid in addressing the challenges posed by global warming and preserving the plankton population.
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