These results demonstrate that sCLU is functionally an important phenotype modulator of PASMCs, and its upregulation in lung tissues may exert a deteriorative role in pulmonary vascular remodelling.

No abstract

Our study suggested 10-repeat allele of 5-HTTVNTR may be associated with TLE susceptibility.

Background:Background: Juvenile myelomonocytic leukemia (JMML) is an aggressive pediatric myeloproliferative disease, but several newly diagnosed patients cannot tolerate hematopoietic stem cell transplantation (HSCT) at diagnosis. Aims:Aims: n the present study, we aimed to explore the short-term effect of decitabine in combination with low-dose chemotherapy on improving the condition of JMML patients before HSCT. Methods:Methods: A total of 10 JMML patients were enrolled in this retrospective analysis. All the patients were treated with decitabine supplemented with low-dose chemotherapy with a interval of 4 weeks, bridging to HSCT after three~four courses. Results: Results:The median treatment course was three (one-five) cycles, and the response rate was 70.0% after one cycle and 71.4% after three cycles. The WBC and monocyte counts were significantly decreased after chemotherapy, and the spleen volume showed a decreasing tendency. The 12-month progression-free survival rate was 80.0±12.6%. Image: Image: Summary/Conclusion: Summary/Conclusion: Decitabine in combination with low-dose chemotherapy was favorable in reducing tumor burden and improving the clinical status.