Somatic mutations of LKB1 tumour suppressor gene have been detected in human cancers including non-small cell lung cancer (NSCLC). The relationship between LKB1 mutations and clinicopathological characteristics and other common oncogene mutations in NSCLC is inadequately described. In this study we evaluated tumour specimens from 310 patients with NSCLC including those with adenocarcinoma, adenosquamous carcinoma, and squamous cell carcinoma histologies. Tumours were obtained from patients of US (n ¼ 143) and Korean (n ¼ 167) origin and screened for LKB1, KRAS, BRAF, and EGFR mutations using RT-PCR-based SURVEYOR-WAVE method followed by Sanger sequencing. We detected mutations in the LKB1 gene in 34 tumours (11%). LKB1 mutation frequency was higher in NSCLC tumours of US origin (17%) compared with 5% in NSCLCs of Korean origin (P ¼ 0.001). They tended to occur more commonly in adenocarcinomas (13%) than in squamous cell carcinomas (5%) (P ¼ 0.066). LKB1 mutations associated with smoking history (P ¼ 0.007) and KRAS mutations (P ¼ 0.042) were almost mutually exclusive with EGFR mutations (P ¼ 0.002). The outcome of stages I and II NSCLC patients treated with surgery alone did not significantly differ based on LKB1 mutation status. Our study provides clinical and molecular characteristics of NSCLC, which harbour LKB1 mutations.
Abstract. TUS (Tracking Ultraviolet Set-up), the first orbital detector of extreme energy cosmic rays (EECRs), those with energies above 50 EeV, was launched into orbit on April 28, 2016, as a part of the Lomonosov satellite scientific payload. The main aim of the mission is to test a technique of registering fluorescent and Cherenkov radiation of extensive air showers generated by EECRs in the atmosphere with a space telescope. We present preliminary results of its operation in a mode dedicated to registering extensive air showers in the period from August 16, 2016, to November 4, 2016. No EECRs have been conclusively identified in the data yet, but the diversity of ultraviolet emission in the atmosphere was found to be unexpectedly rich. We discuss typical examples of data obtained with TUS and their possible origin. The data is important for obtaining more accurate estimates of the nocturnal ultraviolet glow of the atmosphere, necessary for successful development of more advanced orbital EECR detectors including those of the KLYPVE (K-EUSO) and JEM-EUSO missions.
Abstract:We report on design, manufacture, and testing of a Slewing Mirror Telescope (SMT), the first of its kind and a part of Ultra-Fast Flash Observatory-pathfinder (UFFO-p) for space-based prompt measurement of early UV/optical light curves from Gamma-Ray Bursts (GRBs). Using a fast slewing mirror of 150 mm diameter mounted on a 2 axis gimbal stage, SMT can deliver the images of GRB optical counterparts to the intensified CCD detector within 1.5~1.8 s over ± 35 degrees in the slewing field of view. Its Ritchey-Chrétien telescope of 100 mm diameter provides a 17 × 17 arcmin 2 instantaneous field of view. Technical details of design, construction, the laboratory performance tests in space environments for this unique SMT are described in conjunction with the plan for in-orbit operation onboard the Lomonosov satellite in 2013.
In conclusion, our results suggest that low-normal serum TSH levels might be a potential risk factor for the osteoporosis of the lumbar spine in non-obese elderly women. But further prospective, large-scale, randomized controlled studies are warranted to establish our results.
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