Information about the QT interval from surface electrocardiograms (ECGs) is essential for surveillance of the proarrhythmia potential of marketed drugs. However, ECG records obtained in daily practice cannot be easily used for this purpose without labor-intensive manual effort. This study was aimed at constructing an open-access QT database, the Electrocardiogram Vigilance with Electronic Data Warehouse (ECG-ViEW). This longitudinal observational database contains 710,369 measurements of QT and associated clinical data from 371,401 patients. The de-identified database is freely available at http://www.ecgview.org.
Objectives: The objective of this study was to describe racial differences in the prevalence of a cognitive impairment or dementia diagnosis, likelihood of chemoimmunotherapy utilization and subsequent survival in elderly diffuse large B-cell lymphoma (DLBCL) patients. MethOds: We conducted a retrospective cohort study using cancer data from the Surveillance, Epidemiology, and End Results (SEER)-Medicare linked database. We identified Medicare beneficiaries with a first primary DLBCL diagnosis between 2001 and 2011. A validated algorithm for use with administrative claims data was used to determine presence of neurocognitive impairment or dementia diagnosis at baseline and throughout the study period based on International Classification of Diseases, Ninth Revision (ICD-9) and procedural codes. Results: Of the 10,626 Medicare beneficiaries identified with a DLBCL diagnosis, 410 (3.9%) patients also had evidence of a neurocognitive impairment or dementia diagnosis during the study period. The proportion of patients with comorbid neurocognitive impairment or dementia with DLBCL diagnosis was slightly higher among Non-Hispanic Black (6.1%) and Hispanic (4.6%) patients compared to non-Hispanic White (3.7%) and Asian/Pacific Islander (3.3%) patients. In multivariable models, patients with neurocognitive impairment or dementia had significantly lower odds of systemic treatment with chemo-immunotherapy (OR: 0.43; 95% CI: 0.34-0.54) with even lower odds of treatment among Black (OR: 0.16; 95% CI: 0.04-0.48) and Hispanic patients (OR: 0.17; 95% CI: 0.06-0.46). Poorer cancer-specific survival was observed among DLBCL patients with documented neurocognitive impairment or dementia (HR: 1.61, 95% CI: 1.43, 1.81), but this association was attenuated when adjusting for differences in curative treatment received (HR: 1.39, 95% CI: 1.24, 1.57). cOnclusiOns: There are racial differences in neurocognitive impairment and dementia and chemo-immunotherapy utilization among elderly DLBCL patients. Further research is needed to understand patient, caregiver and provider preferences in the care of lymphoma patients with these conditions.
from death statistics of the National Statistical Office. Exposures to antidepressant were assessed during the 7 days prior to death from traffic accident. We set four control periods with same lengths as the hazard periods, and we selected 30 days as washout period. For sensitivity analysis, we applied 14-, 30 days as length of periods. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated by conditional logistic regression. Results: Of 1,304 death from traffic accident (mean age 64.1 ± standard deviation 10.5, 24.9% is female), antidepressant was prescribed to 23% patients. The ORs for death from traffic accident was 0.84 (95% CI 0.31-1.10), and when applying 7, 14 days of hazard periods, the ORs 0.60 (95% CI 0.31-1.16), 0.88 (95% CI 0.45-1.68). The ORs for TCAs and SSRIs was 0.33 (95% CI 0.14-0.81) and 0.70 (95% CI 0.18-2.65). ConClusions: We found no association of the death from traffic accident and antidepressant use, however, decreased risk was observed with TCAs.
A509through Pubmed. All costs were adjusted for inflation to their 2015 equivalent and converted to Irish Euro € using the OECD's PPP conversion rates. Results: Among the 20 countries for which GP consultation costs were found, the reported cost of a consultation ranged from € 7 to € 142. The mean cost was € 46 with a standard deviation of € 36. Cost estimates varied in antiquity from 2007 to 2015. A positive weakly significant correlation was observed between GP costs and a country's per capita GDP. ConClusions: Evident heterogeneity in the cost of a GP consultation reflects more strongly methodological heterogeneity in the estimation of costs than variations in national income. Adapting model-based estimates of cost-effectiveness using local costs without considering the basis upon which costs are constructed will fail to produce comparable estimates of cost-effectiveness.
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