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The microtubule-associated protein tau favors microtubule nucleation and stabilization and plays a role in the elongation of axons. We have investigated the ability of glycogen synthase kinase-3L L (GSK-3L L) to control tau-induced processes outgrowth. Tau-transfected Chinese hamster ovary (CHO) cells developed processes containing microtubule bundles after cytochalasin treatment, but a significant reduction in the number of cells harboring processes was observed in tau/GSK-3L L-cotransfected cells. Lithium, an inhibitor of GSK-3L L, counteracted in a dose-dependent manner this inhibitory effect of GSK-3L L. These findings suggest that GSK-3L L modulates in a graded manner the ability of tau to control the microtubule-dependent induction of cell processes.z 2000 Federation of European Biochemical Societies.

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