In the sera of four fomalo patients with proven IgG-linked creatinc kinase BB (macro crentinc kinasc BB) wo studied the nature of the binding between creatinc kinasc isoonzymes and immunoglobiilin G, The specificily towards the isoenzyme bound, the recombination of the complex after treatment with acid buffer, (he site of the binding between both partners and an apparently monoclonal nature of the immunoglobulin G involved in the complex indicate that a specific antigen-antibody reaction is responsible for the existence of macro creatlne kinasc BB in the sera investigated, Makro-Kreatinkinase-BB: Nachweis einer spezifischen Bindung zwischen Kreaflnklnasc-Oß und /mmunglohntln G Zusammenfassung:In den Seren von vier Patientinnen mit nachgewiesener IgG gebundener Kreatinkinasc-Bß (MakroKreatinkinase-BB) untersuchten wir die Bindung zwischen den Kreatinkinasc-lsocnzymcn und Immunglobulin G. Diese enzymbindcnden Immuiiglobullnc sind durch ihre Spezifitiit charakterisiert und zeichnen sich durch ihre Rokombinationsftlhigkeit zu Makro-Kreatinkinase aus. Die Lokalisation der Bindung auf den Fab-Pragmcnlcn und die offensichtlich monoclonale Herkunft der bindenden Immunglobulinc machen eine Antigcn-Antikörpcr-Rcaktion als Ursache dieser Makro-Krcatinkinase-BB wahrscheinlich.
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