BRITISH 577 and the others are slow reacting substance in anaphylaxis (S.R.S.-A.) and the kinins. Administration of purified extracts of any one or combination of these three substances will cause bronchospasm in experimental animals. The histamine effect only is antagonized by antihistamines. In 1963 Collier and his colleagues demonstrated that bronchospasm, induced by either kinins or S.R.S.-A., could be completely prevented by the administration of a small dose of aspirin a few minutes before the injection of kinins or S.R.S.-A.' Aspirin seemed, in fact, to be a specific antagonist of kinins and S.R.S.-A., and the logical deduction is that combined therapy with aspirin and antihistamines should be an effective prophylactic for at least some cases of extrinsic asthma. Either substance alone would have only a partial and unpredictable effect, which is in accord with the variable and usually disappointing effect of antihistamines in asthma. There is therefore a sound biochemical background for the effect observed by Professor Clarke, although combined therapy with an antihistamine would be more logical. I am aware of no human trials of combined antihistamine/aspirin therapy, and would also like to make it clear that I am quoting only from sight and memory of the work of original researchers.-I am, etc.,
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