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Abstract.Investigation of regulation of estradiol production by porcine granulosa cells is hindered by lack of a culture system that consistently produces estradiol for extended periods. This indicates that WA-cells or some component of these pools of cells interact with TB-cells to reduce estradiol production.We conclude that TB-cells are primarily from the mural layers within the follicle and are more differentiated at time of collection. The means through which TB-cells sustain FSH stimulated estradiol production in culture and why WA-cells fail to achieve this level of production are unknown.

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