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SummaryKetamine and medetomidine produced chemical restraint for minor procedures in mice. Male mice required SOmg/kg ketamine, 10 mg/kg medetomidine intraperitoneally (Lp.), and females a higher dose of ketamine 175 mg/kg i.p.l. The onset of restraint effects, judged by loss of righting reflex, was more rapid in males than females. The effects were reversed using atipamezole (1-2.5 mg/kg). Recovery following administration of atipamezole was more rapid in males than females. We conclude that ketamine/medetomidine, followed by reversal with atipamezole, is an effective technique for chemical restraint in the mouse.

Inhaled sevoflurane therapy decreases the levels of PaCO2 and peak inspiratory pressure values, and it may be considered as a rescue therapy in patients with life-threatening bronchospasm refractory to conventional therapy.

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