We have analyzed the dependence of the serotonin receptor binding affinity on the electronic and steric reactivity indexes for a group of 5-substituted tryptamines. The approaches employed are a new nonempirical Quantitative Structure-Activity relationship approach and multiple regression analyses. The results suggest that the variation of the receptor binding affinity in 5-substituted tryptamines is related to the variation of the net charge of two atoms and to the steric bulk of the N-substituent. A receptor model is proposed.
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