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Views of young people with type 1 diabetes are vital in developing quality services and improving health‐related quality of life (HRQoL), yet research on their lifestyle and use of web and mobile technology to support their condition and in non‐health related areas is sparse. The aim of this research was to develop an insight into young people's current use of web and mobile technology and its potential impact on HRQoL by constructing an in‐depth picture of their day‐to‐day experiences, exploring how they made use of technology in their lives and in relation to their condition and treatment – then, building something to help them. Data were collected by semi‐structured, in‐depth qualitative interviews (n=9) of young people with type 1 diabetes and aged 18–21 years. Interviews were transcribed and loaded onto NVivo for theme identification. Data analysis was also undertaken during initial interviews (n=4) to locate potential ideas for technical development. Latter interviews (n=5) assisted in the iterative sociotechnical design process. Three suggestions for improvement were taken forward for prototyping with one – an alcohol education guide – being developed into a clinically approved app. This article documents the procedures and sociotechnical design principles involved in the creation of a patient‐centric app. It provides an innovative example of how education with the aim of improving HRQoL can be designed in a way which meets the needs of a particular group and values and encourages their input to assist in the creative process, while at the same time conforming to clinical guidelines. Copyright © 2013 John Wiley & Sons.

Abstract. Streptozocin (STZ) induces diabetes mellitus in sheep and pigs. To test the effect of STZ in cattle, cows were given 75-150 mg STZ per kilogram of body weight. Cows receiving 150 mg/kg required euthanasia within 24 hours after infusion because of the severe systemic effects of STZ. Seven cows receiving doses of Յ100 mg/kg had mild to marked decrease in islet immunoreactivity for insulin and in pancreatic islet density and mild to severe tubulointerstitial nephritis. Two cows receiving 75 and 85 mg/kg STZ regained their ability to produce insulin and return blood glucose to basal levels. One cow given 100 mg/kg STZ developed insulin insufficiency consistent with type I diabetes mellitus. These findings demonstrate the susceptibility of the bovine pancreas to STZ; however, severe systemic complications were encountered. Alternative dosages and methodologies should be considered in future attempts to induce diabetes in cattle using STZ.Key words: Cattle; diabetes; experimental disease; immunohistochemistry; insulin; pancreas; streptozocin.Insulin has been implicated in the control of ovarian function in vivo and in vitro in rats, 9 pigs, 13 beef heifers, 5 and humans. 2 Researchers have used an energyrestricted cow model to investigate mechanisms of reduced fertility rates in beef cattle. 1,12,17 In these studies, insulin was reduced in the estrous cycle immediately before nutritionally induced anestrus. However, researchers postulate that both over-and underfed animals may have altered mixed-function oxidase activities in the liver that influence the metabolic clearance rate of reproductive hormones. 21 To offset postulated problems associated with endocrine and metabolic events in nutritionally altered animals, our laboratory designed and implemented studies to develop a chemically induced diabetic cow model conceived as a result of the apparent success observed in manipulating the reproductive events in streptozocin (STZ)-induced diabetic pigs and sheep. 3,13 Streptozocin (2-deoxy-2[[(methyl-nitroamino) carbonyl] amino] ␣ (and ␤)-D-glucopyranose) 14 is a naturally occurring glucosamine-nitrosourea (aminoglycoside) antibiotic derived from the fermentation broth of Streptomyces achromogenes. This compound induces a type I diabetic condition by selectively destroying beta cells within the islets of Langerhans. 23

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