In this contemporary outpatient HFrEF registry, significant gaps in use and dose of guideline-directed medical therapy remain. Multiple clinical factors were associated with medication use and dose prescribed. Strategies to improve guideline-directed use of HFrEF medications remain urgently needed, and these findings may inform targeted approaches to optimize outpatient medical therapy.

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Women with heart failure due to nonischemic causes had significantly better survival than men with or without coronary disease as their primary cause of heart failure.

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The problem addressed is that of scheduling the activities of a project network to minimize project duration under conditions of multiple limited resource requirements and availabilities. Various heuristic sequencing rules have been applied to this problem, and the effectiveness of these rules relative to one another has been previously compared in the literature. However, there have been no previous comparisons of the effectiveness of these rules relative to an optimum solution. This paper makes such a comparison of eight different heuristic scheduling rules, including those found most effective in previous research on this problem. Results are presented for a total of eighty-three different multi-resource problems.

A recurring problem in managing project activity involves the allocation of scarce resources to the individual activities comprising the project Resource conflict resolution decisions must be made whenever the concurrent demand for resources by the competing activities of a project exceeds resource availability. When these resource conflict resolution decisions arise, project managers seek direction on which activities to schedule and which to delay in order that the resulting increase in project duration is the minimum that can be achieved with the given resource availabilities. The procedures examined in this paper are all designed to provide for this type of decision support. Each procedure examined is enumerative based, methodically searching the set of possible solutions in such a way that not all possibilities need be considered individually. The methods differ in the manner in which the tree representing partial schedules is generated and is saved, and differ in the methods which are used to identify and discard inferior partial schedules. Each procedure was found to be generally superior on a specific class of problems, and these classes are identified.project management: resource constraints, programming: integer algorithm, branch and bound, networks/graphs: applications