A simple
set of protocols for the controlled elaboration of anilines
is reported allowing access to a diverse array of aminophenols, aminoarylsulfonates,
alkylated anilines, and aminoanilines in 29–95% yield in a
single laboratory operation from easily isolable, bench-stable N,N-dialkylaniline N-oxides.
The introduction of new C–O, C–C, and C–N bonds
on the aromatic ring is made possible by a temporary increase in oxidation
level and excision of a weak N–O bond.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.