high dose RTX without IS and children given all RTX regimens with IS were significantly lower than in those given the low RTX dose without IS. Adjusted hazard ratios (HR adj ) ranged from 0.33 to 0.44 (ps <0.008). Conclusion Rituximab dose and use of concomitant IS hade important effects on the long-term control of complicated FR/ SDNS. Children given the low dose of RTX without IS had a shorter relapse-free survival than the other children.
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