We wished to investigate the outcome of surgery combined with external-beam radiotherapy (EBRT) or brachytherapy (125 I seeds) for the treatment of primary adenoid cystic carcinoma (ACC) of the oral and maxillofacial region. Data of patients with primary ACC were reviewed retrospectively. Patients were divided into EBRT and brachytherapy groups. Wide tumor excision was done to achieve negative margins. Standard radiotherapy in the EBRT group was 60 Gy. A treatment-planning system was used to create implantation plans with a prescribed dose of 60e 120 Gy and 125 I seeds were implanted postoperatively. KaplaneMeier method and log-rank tests were used to analyze local control and survival. The median duration of followup was 66.1 and 46.8 months for the EBRT group and brachytherapy group, respectively. There was no significant difference in local control, control of metastasis to regional lymph nodes, or control of distant metastasis between the two groups. There was no significant difference in overall survival, disease-specific survival, or disease-free survival in the two groups at 3 years and 5 years. The prevalence of complications in the brachytherapy group was lower than that in the EBRT group. Both methods elicited good treatment effects, but the prevalence of adverse events was lower in the brachytherapy group.
Background: Osteosarcoma is an aggressive bone malignancy rarely presenting in head and neck sites, the trials for extremity osteosarcoma show improved survival by chemotherapy. The head and neck osteosarcomas (HNOs) were excluded in these trials because of atypical presentation and disease course. Further, sufficient numbers were not possible for a trial. Objectives: We present a largest retrospective study from single institute investigating the role of chemotherapy in the management of HNOs.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.