The characteristics of induction with and recovery from isoflurane anaesthesia were studied in 248 children. The mean time to loss of consciousness was 1.5 min (SD 0.5). Tracheal intubation. without interruption ofspontaneous ventilation, was accomplished in a mean time of 4.2 min (SD 54 seconds). Movement andexcitement, of 20-30 secondr duration. occurred in 23.9% children and22patients coughed during induction; 15 (12.6%) during the first 124 inductions; 7 (5.6%) subsequently. The mean hawtimes of reduction of alveolar isoflurane concentrations in 28 children whose lungs were ventilated with isoflurane and in 13 children who breathed isoflurane spontaneously during anaesthesia were: 45 sec after exposure for one hour, 70 sec after exposure of 2-3 hours and 110 second following exposures of 4-8 hours. The mean recovery times of the three groups were 6.5, 9.5 and 11.5 min respectively. In two further groups of nine children the mean h a y times of elimination of halothane and isoflurane were 220 secondr and 54 secondr respectively; recovery from isojlurane was markedly faster.Isoflurane is well accepted by children; induction is more rapid than with halothane, and the markedflexibility in the control of its efl'ects are due to its relative insolubility. It has wide application in paediatric anaesthesia.
SummaryThe characteristics of induction with and recovery from isoflurane anaesthesia were studied in 248 children. The mean time to loss of consciousness was 1.5 min (SD 0.5
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