4-(a>-Hydroxyalkyl)-2-methyI-piperazines were treated with aralkyl and alkyl halides to form twenty-one unsymmetrical l,4-disubstituted-2-methylpiperazines. Three new 4-( -hydroxyalkyl)-2-methylpiperazines were also prepared. A urethane of each of the unsymmetrical l,4-disubstituted-2-methylpiperazines was prepared. All of the above compounds are now being evaluated pharmacologically. 338 (1943338 ( ). Soc., 74, 605 (1952.
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