The rise in plasma adenosine-3',5'-monophosphate occurring in response to insulin induced hypoglycaemia in normal human subjects, was abolished by non-selective ,3-adrenoceptor blockade but unaffected by selective (31-adrenoceptor blockade. This implies that the rise is secondary to /2-adrenoceptor stimulation. The abolition of this rise by non-selective f3-adrenoceptor blockade had no pronounced effect on the recovery from hypoglycaemia. Endogenous opiate receptor blockade with naloxone had no significant effect on the recovery from insulin induced hypoglycaemia, or the hormonal mechanisms involved.

No abstract