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Evidence suggests that personality traits may play a significant role in individual differences in cortisol reactivity in stressful situations. In this study, cortisol responses to public speaking were examined to test hypotheses that reactivity would be positively related to openness, agreeableness, and conscientiousness, and negatively to extraversion, neuroticism, and psychoticism, respectively. A sample of 75 students (56 women and 19 men) completed the NEO Five-Factor Inventory (Costa & McCrae, 1992) and the Eysenck Personality Questionnaire-Revised (Eysenck & Eysenck, 1985), and 2 saliva samples were taken before and after the stressor, and another 2 samples at similar times on a control day. Results revealed that conscientiousness was associated with an enhanced cortisol response to stress, while psychoticism was correlated with a blunted response.

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BackgroundThere is a lack of evidence about the loss of efficacy of anti-TNF agents in JIA and its possible relation to the immunogenicity generated. In the last years there has been interest in the role of serum calprotectin in children diseases, including JIA.ObjectivesTo assess the immunogenicity and bioavailability of anti-TNF drugs, their relationship with disease activity and the clinical utility of serum calprotectin in monitoring JIA patients.MethodsThis is a 12-month prospective, multicenter, non-interventional, observational study. Patients from 2 to 18 years diagnosed with non-systemic JIA according to ILAR criteria and receiving treatment with IFX, ADA or ETN were included. The patients were evaluated using the CHAQ and the juvenile arthritis disease activity score (JADAS 71) and determination of anti-TNF drug, anti-drug antibody and calprotectina serum levels were performed.Results222 patients were included. At month 12, 181 (81.5%) continued receiving treatment, and 205 (94.5%) had positive serum levels of anti-TNF drug (96.2% of ETN, 93.5% of ADA and 66.7% of IFX) at baseline and at 12 months serum levels were positive in 161 (95.3%) patients (97.5% ETN, 93.2% ADA and 100% IFX). In total, 16 (7.3%) patients presented anti-drug A (1 of 106 anti-ETN, 13 of 109 anti-ADA, 2 of 3 anti-IFX) at baseline and 4 patients (2.4%) (0 of 81 anti-ETN, 4 of 88 anti-ADA, 0 of 1 anti-IFX) at 12 months. Regarding the relationship between anti-TNF levels or anti-drug Abs, disease activity, and functional disability overall, statistically significant differences were not observed between the groups. Patients with high levels of serum calprotectin at the baseline visit (16 of 216) showed higher JADAS-71 score [1.23 (2.06 SD) vs. 2.06 (3.44 SD)] and CHAQ [0.11 SD (0.28 SD)] vs 0.17 (0.40 SD)] compared with normal calprotectin group, although no statistically significant differences were observed (p = 0.066 and p = 0.288) between the groups with a normal and high level of serum calprotectin and the number of patients was small.ConclusionThe low prevalence of anti-drug Abs observed was in consonance with the high proportion of patients with a positive serum level of anti-TNF drug. These data suggest an appropriate management of the long-term treatment of Spanish JIA patients, who showed a maintained inactive disease/low disease activity state and a very low functional disability state as a consequence of a low immunogenicity and good bioavailability of anti-TNF drugs.Baseline patients’ characteristics.Table 2 JADAS -71 score according to immunogenicity and bioavailability of anti-TNF drugs Serum anti-TNF (Negative) Serum anti-TNF (Positive) Anti-drug antibodies (Negative) Anti-drug antibodies (Positive) Total Baseline N2219720019221 Mean (SD)1.52 (2.66)1.35 (2.29)1.30 (2.28)1.99 (2.66)1.38 (2.34)p value0.7430.216 Month 12 N2017818216199 Mean (SD)2.19 (2.61)0.94 (1.90)0.98 (1.97)2.06 (2.22)1.08 (2.01)p value0.0090.039Disclosure of InterestsInmaculada Calvo Grant/research support from: received research grants from Pfi...