Pentacene and its derivatives are among the most important examples of π-electron-rich molecules used in organic field effect transistors. The replacement of CH groups by nitrogen atoms opens an elegant way to generate highly electron-deficient molecules, known as oligoazaacenes. We describe the synthesis and spectroscopic properties of two novel derivatives of this family, namely the zwitterionic and quinoidal conjugated forms of dihydro-5,6,7,12,13,14-hexaazapentacene (fluorubine). We outline a powerful strategy to tune the electronic properties of these redox-active azaacenes by the selective introduction of substituted pyrazines. Their acidochromic and solvatochromic behaviour is investigated experimentally and interpreted with the help of theoretical calculations. The simple "exchange" of substituents or protonation is shown to significantly alter the spectroscopic and electronic properties of these remarkably stable π-systems. Their exceptional optical properties, such as high fluorescence quantum yields combined with a redox-active behaviour, make them promising candidates for sensor materials. Additional marked features in the solid state, such as herringbone packing in combination with short π-π distances, will open access to electronic materials.
The established approach to design a molecule with strong second-order nonlinear optical (NLO) activity is to connect an electron-donor to an electron-acceptor via a p-conjugated bridge, to generate push-pull system. Surprisingly, we have found that dyes with large first hyperpolarizabilities, and which exhibit strong second harmonic generation (SHG), can be created just by attaching an electron-donor to a porphyrin. The free-base porphyrin core is sufficiently electron-deficient that the hyperpolarizability does not increase on addition of a pyridinium electron-acceptor.
Evaluation of the response of the arterial vessel wall to acute arterial injury in experimental models has taken on substantial importance because of an increasing interest in angioplasty treatment of human atherosclerotic lesions. In this study, the response of normal arterial vessels to acute balloon injury was studied in 45 iliac artery segments from 24 New Zealand White rabbits fed a 2% cholesterol diet. At specified time points between 1 and 41 days after the initial balloon pullback injury, the iliac arteries were analyzed by angiographic, morphometric, and immunocytochemical techniques. Angiographic measurements indicated progressive compromise of the iliac artery lumen with increasing duration of time from injury. Morphometric measurements showed that intimal area increased from 0.004±0.01 mm 2 3 days after injury to 1.15±0.30 mm 2 34-41 days after injury. Cell line-specific immunocytochemical analysis identified the macrophage as a prominent component of the earliest intimal cellular infiltrate. Smooth muscle cells appeared within the intima 7-9 days after injury. As the intima increased in area, macrophages predominated along the internal elastic lamina aspect of the intimal lesion while smooth muscle cells occupied the portion of the intima adjacent to the lumen. In summary, retrograde balloon pullback injury followed by cholesterol feeding results in progressive arterial luminal narrowing due to a progressively enlarging intimal cellular infiltrate.
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