LHPR with a conversion rate of 14.28% seems to be a method with shorter operating time and less morbidity compared with OHPR.

The photophysical properties of a diphenyl amino-substituted triphenylbenzene, (pEFTP), biphenyl (pEFBP), and fluorene (pEFF) derivative are compared. The similarity of the photophysical properties and their solvent dependence for the triphenylbenzene and the biphenyl model compound indicate the formation of a polar excited state, localized in one branch of pEFTP. Further comparison with the fluorene model compound suggests an excited state relaxation process of the biphenyl moiety in solvents of medium and high polarity toward a more planar geometry. The depopulation of the excited state is explained in the framework of the model developed to rationalize the photophysics of substituted biphenyl.

No abstract

No abstract

Ischemia-reperfusion injury (IRI) after transplantation is a major cause of delayed graft function, which has a negative impact on early and late graft function and improve acute rejection. We have previously shown that polyethylene glycol (PEG) and particularly PEG 20M has a protective effect against cold ischemia and reperfusion injury in an isolated perfused pig and rat kidney model. We extended those observations to investigate the role of PEG using different doses (30g or 50g/l) added (ICPEG30 or ICPEG50) or not (IC) to a simplified preservation solution to reduce IRI after prolonged cold storage (48-h) of pig kidneys when compared with Euro-Collins and University of Wisconsin solutions. The study of renal function and medulla injury was performed with biochemical methods and proton NMR spectroscopy. Histological and inflammatory cell studies were performed after reperfusion (30 -40 min) and on days 7 and 14 and weeks 4, 8, and 12. Peripheral-type benzodiazepine receptor (PBR), a mitochondrial protein involved in cholesterol homeostasis, was also studied. The results demonstrated that ICPEG30 improved renal function and reduced medulla injury. ICPEG30 also improved tubular function and strongly protect mitochondrial integrity. Post-IRI inflammation was strongly reduced in this group, particularly lymphocytes TCD4 ϩ , PBR expression was influenced by IRI in the early period and during the development of chronic dysfunction. This study clearly shows that PEG has a beneficial effect in renal preservation and suggests a role of PBR as a marker IRI and repair processes.

Ischemia-reperfusion injury (IRI) represents an alloindependent risk factor which favors chronic allograft nephropathy (CAN).

No abstract

No abstract