Abstract. T he T ulsa Regi stry of Canine and Fe line Neopl asms was the second anima l tumor regist ry in the U nited Sta tes conce rned with a defin ed populati on in a delimited geographic area . Only tumors histo logica lly confi rmed by registry pa tho logists were incl ude d in freq uenc y statistics based on the ann ua l dog and ca t pop ulatio n present ed to veterinarians .During the first registry year, abo ut 1% of the 63,504 dogs and 0.5% of the 11,909 cats had one or more primary tum or s. While the incidence ra te for ma lignan t tu mor s in dogs was similar to th at in cat s, the incidence of benign tumors of dogs was ove r 10 times that of cats . The most commo n tum ors were sebaceous adenoma in dogs and lymp hosarcoma in cats. Mammary cancer was the most commo n malignant tu mor in dogs . Mammary tumo rs of fema le dogs were significantly more frequent in Poi nte rs, Poodl es and Boston Te rrie rs, in that order , than in other breeds. A greater incidence of mam ma ry tumors amo ng intact compa red to spa yed fema le dogs was seen for virtually every age grou p except in the Pointer breed .In veterinary medicine, the lack of census, certification of death, and registries of neoplasms have precl uded epidemiological studies compa ra ble to those of neopl asms of man . Because of di fferent organizatio nal struc tures and de fined reference populations, ani mal neoplasm registries have different limitations. Animal tum or registry statistics based upon estimated populations derived from enumera tion of licensed or vaccina ted ani mals [2,8,17] have suffered from populati on (deno mina tor) und erestimation beca use of the low response of the public in licen sing or vaccinating thei r pets. Ot her tu mor registries based on submissions to veterina ry medical teaching hospitals [3,12] are no t representa tive of the tum or cases (nume rators) becau se of referrals and the lack of clear defi nition of the geographic areas served. In addition to important descriptive informat ion, these studies have provided indications of possible variations in tum or occurrence between broad geographic areas . The variations per ha ps are related to regional differences in breed popularity, in the distributions of other host characteristics such as age or sex or different env iro nme nta l exposures, including veterinary medica l care.The first registry based on collections of tumo rs submitted from all veterinary hospitals within a defi ned geographic region was esta blished in 1963 in California 70 0

Abstract. Ductal carcinomas accounted for nearly all metastases seen in epithelial canine mammary tumors submitted to the Tulsa Registry of Canine and Feline Neoplasms in a 4-year period from a defined canine population. Lobular and squamous cell carcinomas were the only other metastatic carcinomas seen. Early ductal carcinoma was used to indicate nonmetastatic ductal carcinoma with a favorable post-surgical prognosis. Benign epithelial tumors were categorized as adenoma, ductal papilloma and squamous cell papilloma. Progressive transformation of well defined adenomas and papillomas to carcinoma was not evident in histologic preparations.Squamous metaplasia was seen in many ductal papillomas and ductal carcinomas. Inclusion of pseudocartilage and pseudoosteoid and osteoid, cartilage and bone with ductal carcinomas, adenomas and ductal papillomas seemed related to secretions escaping from neoplastic epithelial cells into stroma or between proliferating tumor cells. There was proliferation and perhaps even neoplastic transformation of myoepithelial cells in some of these tumors. Changes in myoepithelium, however, appeared to be secondary to neoplastic transformation of epithelium. Bone and cartilage in these tumors were considered heterotopic with no neoplastic potential.

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