CD44H and V6 are frequently expressed in Barrett's oesophagus. The pattern of expression that we observed from mucosa negative for dysplasia to adenocarcinoma suggests that CD44H and V6 may be involved in the carcinogenesis of Barrett's mucosa. CD44V6 expression in adenocarcinoma is correlated to aggressive pathological features.
Brief reports 487 similar to that of the amyloid-like deposits in the liver. No such deposits were detected in other organs.
DiscussionPositivity of Congo red stain depends on the antiparallel 8-pleated sheet arrangement of amyloid. Recently, Congo red-negative amyloid-like deposits (immunotactoid) in the kidney have been reported6. Esparza et aL6 reported that light chains, particularly kappa chain, may be involved in the pathogenesis of such immunotactoid glomerulopathy. The deposits in our case were negative with the Congo red stain and immunohistochemically positive for lambda light chain, suggesting that the deposits were immunotactoid or light chain deposit disease. It is possible in our case that the deposits of light chains were in the process of polymerization into fibrils that had not yet assumed a 8-pleated configuration. The ultrastructural observations suggest that the deposits were amyloid-related proteins.Recently, amyloid deposition in intrahepatic bile ducts was reported in systemic amyloidosis'. Such deposition of amyloid in the intrahepatic biliary tree did not produce clinical manifestations'. Our case disclosed clearly that amyloid or immunotactoids can be deposited in the bile ducts to the extent that its deposition can cause biliary obstruction. Thus, it must be emphasized that deposition of amyloid or immunotactoids can occur exclusively in the bile ducts and can cause obstructive jaundice.
References1. Looi LM. Sumithran E. Morphologic difference in the pattern of liver infiltration between systemic AL and AA amyloidosis. Hum. Pathol. 2. Sasaki M. Nakanuma Y . Terada T et al. Amyloid deposition in intrahepatic large bile ducts and peribiliary glands in systemic amyloidosis. Hepatology 1990; 12; 743-746. 3. Levy M. Fryd DH. Eliakin M. Intrahepatic obstructive jaundice due to amyloidosis of the liver: a case report and review of the literature. Gastroenterology 197 1; 61; 234-238. 4. Rubinow A, Koff RS, Cohen AS. Severe inkahepatic cholestasis in primary amyloidosis: a report of four cases and a review of the literature. Am. I. Med. 1978: 64; 937-946. 5. Finkelstein SD, Fornasier VL, Pruzanski W. Intrahepatic cholestasis with predominant pericentral deposition in systemic amyloidosis. Hum. Pathol. 1981; 12; 470-472. 6. Esparza AR. Chazan JA, Nayak RN. Cavallo T. Fibrillary (immunotactoid) glomerulopathy: a possible role for kappa light chain in its etiology and/or pathogenesis. Am. I. Surg. Pathol.
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