Intradermal injection of tacrolimus at 0.5 mg/cm(2) is an efficient way to prevent HSc in our experiment model and its tolerance is correct. Optical spectroscopy could be a good non-invasive tool to evaluate HSc treatment. These promising results might be proposed for patients suffering from keloid.
The association of cannabis use and suicidal ideations in adolescents and young adults has been inconsistent. This discrepancy may reflect differences in controlled confounders but also the lack of consideration of the relationships between confounders. In particular, few studies have examined whether controlled variables mediated rather than confounded the relationship between cannabis use and suicide. Participants were 1034 college students who completed questionnaires assessing cannabis use and symptoms of cannabis use disorder (CUD), suicidal ideation, depressive and anxiety symptoms, and borderline personality traits. The dichotomic variable cannabis use versus non-use was not a significant independent predictor of suicidal ideation. Among cannabis users, the association between symptoms of CUD and suicidal ideation was significant before adjustment for confounding variables. The loss of significance of this association after control for confounders reflected the mediating effects of depressive symptoms and borderline traits on the relationship between symptoms of CUD and suicidal ideation.
The relationships between borderline and schizotypal traits are still debated. Borderline traits, schizotypal traits, and several psychopathological symptoms were assessed among 2,341 college students. A factor analysis was performed on borderline and schizotypal personality measures, leading to 10 factors. Borderline factors were largely intercorrelated, as were schizotypal factors. Moreover, borderline factors were weakly to largely correlated to schizotypal factors. Five factors were very strongly correlated (r > .50). Dissociation was strongly related to Odd Beliefs/Unusual Perceptive Experiences and Anxious-Depressive factors. Social Anxiety was strongly related to Suspiciousness. Based on these 10 factors, a cluster analysis was conducted, and resulted in four clearly distinct groups: a Low Traits cluster, a Narcissistic cluster, a Social Anxiety cluster, and a High Traits cluster. This High Traits cluster had the lowest levels of academic achievement and the highest levels of internalizing behaviors and externalizing behaviors. The clinical implications of the results are discussed.
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